Biotargeting

Panteliou D. Sofia
Associate Professor
Born in Corfu-Greece, two Children.
Mechanical Engineer, University of Patras, (1977). Ph.D. in Mechanical Engineering, University of Patras, (1984).
Languages: Greek, English, French, Italian, German.
Affiliations: Greek Technical Chamber, Greek Association of Mechanical Engineers, ASME.
Tel: 30-2610 - 997 206, Fax: 30-2610 - 997 207
E mail:
http://www.mech.upatras.gr/~panteliu

Research and Academic Activity
Dynamic behavior of thermo-mechanical continua. Design of Mechanical and biomechanical systems. Analytical and experimental method based on change in thermodynamic damping has been developed for the assessment of structural integrity. The method identifies crack propagation and change in porosity. The method applies in monitoring of the dynamic behavior of structures made out of conventional and advanced materials, ceramics, composites, etc., (aircraft design, porous materials, healing of fractures in bones and metabolic diseases of bones i.e. osteoporosis, assessment of mandible bone quality in order to decide for dental implant placement).
The research findings suggest the following applications:
•    Monitoring of structural integrity.
•    Continuous quality control for the production of ceramics, metals, glass, and other materials, sensitive to porosity and crack initiation.
•    Design of materials with reduced noise, for which damping due to porosity plays a paramount role.
•    Crack detection in mechanical structures or bones.
Design and construction of dedicated devices has been performed. The devices have been used to measure bone integrity (quality) in vivo and in vitro (clinical applications on humans and animal subjects).
Besides, methodology has been developed for the assessment of the mechanical properties of the prostate gland, in replacement of the subjective digital rectal examination performed by the urologist. A prototype device and appropriate genuine algorithm have been developed, with which geometric mapping and stiffness representation can be achieved, thus enabling to support the diagnosis for hyperplasia and prostate cancer.